Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2
Abstract
The adipose tissue is regarded as an endocrine organ and secretes bioactive adipokines modulating chronic inflammation and oxidative stress in obesity. Gal-9 is secreted out upon cell injuries, interacts with T-cell immunoglobulin-3 (Tim-3) and induces apoptosis in activated Th1 cells. Gal-9 also binds to protein disulfide isomerase (PDI), maintains PDI on surface of T cells, and increases free thiols in the disulfide/thiol cycles. To explore...
Paper Details
Title
Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2
Published Date
Mar 16, 2021
Journal
Volume
11
Issue
1
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