The Interface Between Inflammatory Mediators and MicroRNAs in Plasmodium vivax Severe Thrombocytopenia

Severe thrombocytopenia can be a determinant factor in the morbidity of Plasmodium vivax , the most widespread human malaria parasite. Although immune mechanisms may drive P. vivax -induced severe thrombocytopenia (PvST), the current data on the cytokine landscape in PvST is scarce and often conflicting. Here, we hypothesized that the analysis of the bidirectional circuit of inflammatory mediators and their regulatory miRNAs would lead to a...