A Vaspin–HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease
Abstract
Proximal tubular cells (PTCs) are crucial for maintaining renal homeostasis, and tubular injuries contribute to progression of diabetic kidney disease (DKD). However, the roles of visceral adipose tissue-derived serine protease inhibitor (vaspin) in the development of DKD is not known. We found vaspin maintains PTCs through ameliorating ER stress, autophagy impairment, and lysosome dysfunction in DKD. Vaspin −/− obese mice showed enlarged and...
Paper Details
Title
A Vaspin–HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease
Published Date
Mar 19, 2021
Journal
Volume
4
Issue
1
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