Pharmacokinetic interaction between peimine and paeoniflorin in rats and its potential mechanism

Peimine and paeoniflorin can be combined for the treatment of cough in paediatrics. The interaction during the co-administration could dramatically affect the bioavailability of drugs.The interaction between peimine and paeoniflorin was investigated in this study.The pharmacokinetics of paeoniflorin (20 mg/kg) with or without the coadministration of peimine (5 mg/kg for 10 days before paeoniflorin) was orally investigated in Sprague-Dawley rats...