The architecture of the SARS-CoV-2 RNA genome inside virion
Abstract
SARS-CoV-2 carries the largest single-stranded RNA genome and is the causal pathogen of the ongoing COVID-19 pandemic. How the SARS-CoV-2 RNA genome is folded in the virion remains unknown. To fill the knowledge gap and facilitate structure-based drug development, we develop a virion RNA in situ conformation sequencing technology, named vRIC-seq, for probing viral RNA genome structure unbiasedly. Using vRIC-seq data, we reconstruct the tertiary...
Paper Details
Title
The architecture of the SARS-CoV-2 RNA genome inside virion
Published Date
Jun 24, 2021
Journal
Volume
12
Issue
1
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