The anti-breast cancer property of physcion via oxidative stress-mediated mitochondrial apoptosis and immune response

Physcion (Phy) exerts several pharmacological effects including anti-inflammatory, antioxidant, and antitumor properties.This study investigates the cytotoxicity and its underlying mechanisms of Phy on breast cancer.Human breast cancer cell MCF-7 was treated with 5-400 µM Phy for 24 h, MCF-7-xenografted BALB/c nude mice and immunosuppressive mice model induced by cyclophosphamide were intraperitoneally injected with 0.1 mL/mouse normal saline...