Internal medicine

Pathology

Pediatrics

Disease

Coronavirus disease 2019 (COVID-19)

Infectious disease (medical specialty)

Pandemic

Etiology

Intensive care medicine

Dermatology

Immunology

Coronavirus

Neuropathology

Pneumonia

Differential diagnosis

Malaise

Trigeminal neuralgia

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Anesthesia

Respiratory system

Medicine

Headache The Journal of Head and Face Pain

Objective To describe a case report of trigeminal neuralgia (TN) due to coronavirus disease‐2019 (COVID‐19). Background In March 2020, the World Health Organization declared COVID‐19 as a pandemic. Respiratory system manifestations are dominant in this new disease. However, numerous case series and reviews have been published on the neurological manifestations, highlighting the potential neurotropism of the new coronavirus. Methods We describe a clinical case of TN during COVID‐19 and we discuss the differential diagnosis and the potential pathogenic mechanism according to the literature. Results A 65‐year‐old man with general malaise and typical respiratory symptoms of COVID‐19, who presented with paroxysmal lancinating pain in the right V1 trigeminal territory without other neurological symptoms. General blood test and neuroimaging study were normal. A rapid test showed positive IgG and IgM serologies for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). The patient was diagnosed with TN secondary to a viral infection by SARS‐CoV‐2. Facial pain resolved with the improvement of COVID‐19. Conclusions The new coronavirus SARS‐CoV‐2 is a possible etiology of secondary TN. Nevertheless, more studies are needed to elucidate the neuropathology of this viral infection.

Trigeminal neuralgia as the sole neurological manifestation of COVID‐19: A case report