Reducing Radiation-Induced Cognitive Toxicity: Sparing the Hippocampus and Beyond

The hippocampi, bilateral subcortical structures that play a fundamental role in learning and memory and are implicated in posttreatment cognitive toxicity after brain radiation therapy (RT), have gained tremendous attention in recent years. Early data from rodent models identified a relationship between increased apoptosis and reduced production of neural progenitor cells in the dentate gyrus of the hippocampus and progressive cognitive decline...