Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury
Abstract
Mitochondria are the major organelles for the formation of reactive oxygen species (ROS) in the cell, and mitochondrial dysfunction has been described as a key factor in the pathogenesis of cholestatic liver disease. The methylation-controlled J-protein (MCJ) is a mitochondrial protein that interacts with and represses the function of complex I of the electron transport chain. The relevance of MCJ in the pathology of cholestasis has not yet been...
Paper Details
Title
Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury
Published Date
Jun 1, 2021
Journal
Volume
3
Issue
3
Pages
100276 - 100276
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