Attenuated TGFB signalling in macrophages decreases susceptibility to DMBA-induced mammary cancer in mice

Volume: 23, Issue: 1
Published: Mar 24, 2021
Abstract
Transforming growth factor beta1 (TGFB1) is a multi-functional cytokine that regulates mammary gland development and cancer progression through endocrine, paracrine and autocrine mechanisms. TGFB1 also plays roles in tumour development and progression, and its increased expression is associated with an increased breast cancer risk. Macrophages are key target cells for TGFB1 action, also playing crucial roles in tumourigenesis. However, the...
Paper Details
Title
Attenuated TGFB signalling in macrophages decreases susceptibility to DMBA-induced mammary cancer in mice
Published Date
Mar 24, 2021
Volume
23
Issue
1
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