Erythropoietin administration expands regulatory T cells in patients with autoimmune hepatitis

Autoimmune hepatitis (AIH) is a chronic liver disease associated with impaired regulatory T cell (Treg) number and function. Erythropoietin (EPO) is a kidney-produced erythropoietic hormone that has known immune-modulating effects, including Treg induction. Whether EPO administration increases Treg in patients with AIH is unknown.We treated six stable AIH patients with a single 1000 IU dose of EPO and comprehensively characterized changes in...