Stability of monoclonal antibodies after simulated subcutaneous administration
Abstract
Changes in the environment from the drug product to the human physiology might lead to physical and/or chemical modifications of the protein drug, such as in vivo aggregation and fragmentation. Although subcutaneous (SC) injection is a common route of administration for therapeutic proteins, knowledge on in vivo stability in the SC tissue is limited. In this study, we developed a physiologic in vitro model simulating the SC environment in...
Paper Details
Title
Stability of monoclonal antibodies after simulated subcutaneous administration
Published Date
Mar 1, 2021
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