Peripheral Nerve Resident Macrophages and Schwann Cells Mediate Cancer-Induced Pain
Abstract
Although macrophages (MΦ) are known to play a central role in neuropathic pain, their contribution to cancer pain has not been established. Here we report that depletion of sciatic nerve resident MΦs (rMΦ) in mice attenuates mechanical/cold hypersensitivity and spontaneous pain evoked by intraplantar injection of melanoma or lung carcinoma cells. MΦ-colony stimulating factor (M-CSF) was upregulated in the sciatic nerve trunk and mediated...
Paper Details
Title
Peripheral Nerve Resident Macrophages and Schwann Cells Mediate Cancer-Induced Pain
Published Date
Mar 26, 2021
Journal
Volume
81
Issue
12
Pages
3387 - 3401
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