Cancer-associated cells release citrate to support tumour metastatic progression
Abstract
Citrate is important for lipid synthesis and epigenetic regulation in addition to ATP production. We have previously reported that cancer cells import extracellular citrate via the pmCiC transporter to support their metabolism. Here, we show for the first time that citrate is supplied to cancer by cancer-associated stroma (CAS) and also that citrate synthesis and release is one of the latter’s major metabolic tasks. Citrate release from CAS is...
Paper Details
Title
Cancer-associated cells release citrate to support tumour metastatic progression
Published Date
Mar 23, 2021
Journal
Volume
4
Issue
6
Pages
e202000903 - e202000903
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History