P60.08 Impact of CD24 and CD47 Tumor Expression on Efficacy and Serum Cytokine Alteration with PD-1/L1 Inhibitors in Non-Small Cell Lung cancer.

To prime tumor-specific lymphocytes, it is crucial that antigen-presenting cells phagocytose tumor cells and process the antigen to load peptides into major histocompatibility complex class I or II molecules. Although enhanced efficacy of the combination of PD-1 inhibitors with inhibitors of CD47, a potent phagocytosis inhibitor, underline the importance of such a mechanism that begins with the phagocytosis, the association of...