Polygenic basis and biomedical consequences of telomere length variation

Abstract
Telomeres, the end fragments of chromosomes, play key roles in cellular proliferation and senescence 1 . Here we characterize the genetic architecture of naturally-occurring variation in leucocyte telomere length (LTL) and identify causal links between LTL and biomedical phenotypes in 472,174 well-characterized participants in UK Biobank 2 . We identified 197 independent sentinel variants associated with LTL at 138 genomic loci (108 novel)....
Paper Details
Title
Polygenic basis and biomedical consequences of telomere length variation
Published Date
Mar 24, 2021
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