INPP5E controls ciliary localization of phospholipids and the odor response in olfactory sensory neurons

Volume: 135, Issue: 5
Published: May 11, 2021
Abstract
The lipid composition of the primary cilia membrane is emerging as a critical regulator of cilia formation, maintenance and function. Here, we show that conditional deletion of the phosphoinositide 5'-phosphatase gene Inpp5e, mutation of which is causative of Joubert syndrome, in terminally developed mouse olfactory sensory neurons (OSNs), leads to a dramatic remodeling of ciliary phospholipids that is accompanied by marked elongation of cilia....
Paper Details
Title
INPP5E controls ciliary localization of phospholipids and the odor response in olfactory sensory neurons
Published Date
May 11, 2021
Volume
135
Issue
5
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