The second phase of brain trauma can be controlled by nutraceuticals that suppress DAMP-mediated microglial activation

Volume: 21, Issue: 5, Pages: 559 - 570
Published: Apr 5, 2021
Abstract
A delayed second wave of brain trauma is mediated in large part by microglia that are activated to a pro-inflammatory M1 phenotype by DAMP proteins released by dying neurons. These microglia can promote apoptosis or necrosis in neighboring neurons by producing a range of pro-inflammatory cytokines and the deadly oxidant peroxynitrite. This second wave could therefore be mitigated with agents that blunt the post-traumatic M1 activation of...
Paper Details
Title
The second phase of brain trauma can be controlled by nutraceuticals that suppress DAMP-mediated microglial activation
Published Date
Apr 5, 2021
Volume
21
Issue
5
Pages
559 - 570
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