Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway

Euphopepluanones F − K ( 1 − 4 ), four new jatrophane type diterpenoids were isolated from the seeds of Euphorbia peplus , along with eight known diterpenoids ( 5 − 12 ). Their structures were established on the basis of extensive spectroscopic analysis and X-ray crystallographic experiments. The new compounds 1 − 4 were assessed for their activities to induce lysosomal biogenesis through LysoTracker Red staining. Compound 2 significantly...