Architectural aspects of cell-blocks as small biopsies

Published on Mar 4, 2021in CytoJournal2.091
· DOI :10.25259/CYTOJOURNAL_4_2021
Swati Satturwar4
Estimated H-index: 4
(University of Pittsburgh),
Liron Pantanowitz59
Estimated H-index: 59
(UM: University of Michigan)
Cell-block preparations have become an essential part of integrated cytology diagnosis. They are essentially microbiopsies that are formalin fixed and embedded in paraffin. This has become more prevalent with greater sample procurement due to the advent of newer biopsy techniques and needles. Cell-blocks allow retrieval of small tissue fragments from cytology specimens that sometimes cannot be processed by alternate cytologic techniques. They represent concentrated, cell-enriched preparations that provide cytologists with the opportunity to evaluate cellular architecture, as well as to perform ancillary testing. A cell-block compatible sample may thus obviate the need for a more invasive procedure such as a tissue biopsy. Microscopic examination of cell-blocks is quick, avoids obscuring material, permits cells to be evaluated in one focal plane, and allows the histologic architecture such as glandular differentiation, papillary formations, and sometimes invasion to be easily identified. This new era of "cytohistology" accordingly requires practicing cytologists to become more familiar with histopathology. This review article discusses the benefit of various architectural patterns identifiable in cell-blocks employed as an adjunct to Pap tests, exfoliative fluid specimens, and fine-needle aspirations.
#1Evi Abada (WSU: Wayne State University)H-Index: 1
#2Kathleen George (WSU: Wayne State University)H-Index: 2
Last. Vinod B. Shidham (WSU: Wayne State University)H-Index: 23
view all 3 authors...
#1Jianming Li (Capital Medical University)H-Index: 1
#2Huarong LiH-Index: 1
Last. Linxue Qian (Capital Medical University)H-Index: 1
view all 5 authors...
OBJECTIVE: To compare the value of the thyroid imaging reporting and data system proposed by Kwak (KWAK TI-RADS) and the 2015 American Thyroid Association (ATA) guidelines for diagnosis of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC). To confirm the role of cell block (CB)-assisted fine-needle aspiration (FNA) in final diagnosis of MTC. DESIGN: Retrospective hospital-based cohort study. PATIENTS: Ninety-three patients with 29 MTCs, 31 PTCs and 33 thyroid adenomas (TAs)...
#1Zenta MasekiH-Index: 1
#2Hiroaki Kajiyama (Nagoya University)H-Index: 58
Last. Fumitaka Kikkawa (Nagoya University)H-Index: 68
view all 6 authors...
The cell block (CB) technique is a generalized method utilized for the diagnostic evaluation of body cavity fluids. Ascites cytology is one of the most important diagnostic processes for epithelial ovarian cancer. However, in clinical practice, the usefulness of the CB method to diagnose this tumor remains unelucidated. Between 2008 and 2017, 15 peritoneal or pleural fluid samples obtained from patients with ovarian or peritoneal carcinoma or other gastrointestinal malignancies were preoperative...
#1Swati Satturwar (University of Pittsburgh)H-Index: 4
#2Sara E. Monaco (University of Pittsburgh)H-Index: 22
Last. Liron Pantanowitz (University of Pittsburgh)H-Index: 59
view all 4 authors...
INTRODUCTION: Telecytology for second opinion consultation has largely been limited by technical issues, such as the inability to focus well on cellular material. Nevertheless, international telecytology consultation was undertaken at our institution with partners in China and Italy. To overcome issues with scanning cytology slides, we adopted a cell-block (CB) preference for teleconsultation. METHODS: Telecytology consultation cases received over a 7.5-year period were retrospectively reviewed....
#3Gülru PolatH-Index: 5
#4Mine GayafH-Index: 3
Last. Zekiye AydoğduH-Index: 2
view all 10 authors...
Aim: The aim of this study wass to compare the cytological features of pleural exudative fluids by conventional smear (CS) method and cell block (CB) method and also to assess the utility of the combined approach for cytodiagnosis of these effusions. Materials and Methods: In all, 113 pleural exudative fluid samples were subjected to evaluation by both CS and CB methods over a period of 2 years. Cellularity, architecture patterns, morphological features, and yield for malignancy were compared, u...
#1Jesse Vance (Texas Tech University Health Sciences Center at El Paso)H-Index: 2
#2Karen Durbin (Texas Tech University Health Sciences Center at El Paso)H-Index: 1
Last. Syed M. Gilani (Texas Tech University Health Sciences Center at El Paso)H-Index: 1
view all 4 authors...
BACKGROUND: This study was conducted to evaluate the diagnostic utility of cell block material in fine needle aspiration (FNA) of thyroid nodules. DESIGN: A total of 242 thyroid fine need aspirations (FNAs) were performed between January 2015 and December 2015. Of those, all consecutive thyroid FNA cases with cell blocks (n = 140) from 129 patients (age: 58.9 ± 12.8 years) are included in this study. Cytology slides and cell blocks are reviewed for adequacy assessment based on the Bethesda Syste...
#1Megan J. Fitzpatrick (Harvard University)H-Index: 8
#2Yasmin G. Hernandez-Barco (Harvard University)H-Index: 3
Last. Martha B. Pitman (Harvard University)H-Index: 55
view all 6 authors...
Introduction Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the standard diagnostic procedure for many intrathoracic and intra-abdominal lesions. Next-generation fine-needle biopsies (FNBs) can increase diagnostic yield by procuring tissue suitable for histological processing. We evaluate the diagnostic yield and operating characteristics of the SharkCore (SC; Medtronic Corp., Minneapolis, MN) FNB in a tertiary referral facility. Materials and methods We performed a single-cent...
#1Vinod B. Shidham (WSU: Wayne State University)H-Index: 23
Cell-blocks are paraffin-embedded versions of cytology specimens comparable to the formalin-fixed paraffin-embedded (FFPE) tissue from surgical pathology specimens. They allow various elective ancillary studies on a variety of specimens with enhanced cytopathologic interpretation, including opportunity to perform molecular tests. However, different dictionaries and internet search engines primarily project “cellblock” and “cell block” definition in relation to prisons. Most of the top searches l...
: Background: Liquid based cytology with dual biomarkers has improved sensitivity and specificity in detecting high grade cervical intraepithelial neoplasia (CIN). In low resource settings, especially in organized camps, LBC is costly and immunohistochemistry on conventional pap smears is difficult to standardize with consumption of lots of reagents. In present study, to improve the accuracy of conventional pap smears and reduce the cost of biomarker testing, we evaluated conventional cell block...
#1Kossivi Dantey (Allegheny General Hospital)H-Index: 1
#2Liron Pantanowitz (University of Pittsburgh)H-Index: 59
Last. Sara E. Monaco (University of Pittsburgh)H-Index: 22
view all 6 authors...
Introduction Urine cytology is a common non-invasive test to screen for urothelial carcinoma. Urine cell blocks may sometimes be prepared as a diagnostic aid (eg, to characterize architecture or perform immunohistochemistry). The aim of this study was to determine whether routinely preparing cell blocks on urine specimens improves diagnostic sensitivity. Materials and methods Three time periods were compared: time period 1 (prior to November 2009; 1437 consecutive selected cases), when cell bloc...
Cited By4
Introduction null Peritoneal malignant mesothelioma is an extremely rare tumor and is a difficult diagnosis to be made on cytology alone. We report 3 cases where the cytologic features were misdiagnosed as carcinoma/lymphoma but histopathology and immunohistochemistry (IHC) established the diagnosis of malignant mesothelioma. null null null Clinical details null Case 1 was a 60-year-old man with multiloculated ascites and omental caking. Peritoneal fluid was reported as malignant on cytology but...
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.