Original paper

Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology

Neuron16.20
Volume: 109, Issue: 8, Pages: 1283 - 1301.e6
Published: Apr 1, 2021
Abstract
Loss-of-function TREM2 mutations strongly increase Alzheimer’s disease (AD) risk. Trem2 deletion has revealed protective Trem2 functions in preclinical models of β-amyloidosis, a prominent feature of pre-diagnosis AD stages. How TREM2 influences later AD stages characterized by tau-mediated neurodegeneration is unclear. To understand Trem2 function in the context of both β-amyloid and tau pathologies, we examined Trem2 deficiency in the pR5-183...
Paper Details
Title
Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology
Published Date
Apr 1, 2021
Journal
Volume
109
Issue
8
Pages
1283 - 1301.e6
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