Clinical Characteristics of Low Androgen Status in Males with Type 2 Diabetes Mellitus.

Published on Feb 1, 2021in Acta Medica Okayama0.642
· DOI :10.18926/AMO/61424
Jun Hamahara1
Estimated H-index: 1
(Okayama University),
Hiroyuki Honda1
Estimated H-index: 1
(Okayama University)
+ 7 AuthorsFumio Otsuka35
Estimated H-index: 35
(Okayama University)
Sources
Abstract
To determine the clinical characteristics of low androgen status in adult males with diabetes, we retrospectively analyzed the medical records of patients with type 2 diabetes mellitus in whom serum free testosterone (FT) levels were examined for 1 year. Among the 46 patients (56 ± 1.5 years old), decreases in serum FT levels to < 8.5 pg/ml (indicating the occurrence of late-onset hypogonadism [LOH]) were detected in 18 (39%). The per-centages of patients with low FT levels were high in the ≥ 50 years age group (83%), the HbA1c < 7% group (67%), and the 25 ≤ BMI < 30 kg/m2 group (56%). The serum FT levels tended to decrease age-dependently. The level of HbA1c was significantly correlated with the Heinemann Aging Male Symptoms (AMS) score (R = 0.47). The low-FT group had decreased levels of hemoglobin. Of note, the serum FSH level (R = -0.32) was negatively correlated with the serum FT level, whereas the serum TSH level (R = 0.36) was positively correlated with the serum FT level. Collectively, these results revealed that many diabetic males may have low FT levels and that the AMS score is related to the HbA1c level. A slightly anemic condition, thyroid dysfunction, and obesity (class 1) might be involved in LOH in middle-aged diabetic males.
References15
Newest
#1Ko Harada (Okayama University)H-Index: 3
#2Yoshihisa Hanayama (Okayama University)H-Index: 4
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 6 authors...
AbstractPurpose: The aim of the present study was to determine how age-related decreases in serum dehydroepiandrosterone sulfate (DHEAS) levels affect various physiological processes.Methods: We re...
2 CitationsSource
#1Patrícia C. Braga (University of Porto)H-Index: 1
#2Sara C. Pereira (University of Porto)H-Index: 2
Last. Marco G. Alves (University of Porto)H-Index: 34
view all 7 authors...
BACKGROUND: Late-onset hypogonadism (LOH) is a condition defined by low levels of testosterone (T), occurring in advanced age. LOH is promoted by senescence, which, in turn, has negative effects on male fertility. Interestingly, the impact of metabolic disorders on the male reproductive system has been the topic of several studies, but the association with LOH is still debatable. OBJECTIVES: Herein, we discuss the hypothesis that the prevalence of metabolic abnormalities potentiates the effects ...
6 CitationsSource
#1Yu Suganami (Okayama University)H-Index: 1
#2Kosuke Oka (Okayama University)H-Index: 2
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 9 authors...
To clarify the potential relevance of patients' chief complaints at a general medicine department to their self-rating depression scale (SDS) and frequency scale for symptoms of gastroesophageal reflux disease (GERD) (FSSG) scores, we analyzed data of 478 patients who visited our general medicine department. The chief complaints (553 symptoms of 447 patients) were categorized into major symptom-based groups: respiratory (31%), circulatory (3%), gastrointestinal (GI) tract (26%), neurology (8%), ...
2 CitationsSource
#1Anna Miura (Tokyo Medical and Dental University)H-Index: 6
#2Trang T H Tu (Tokyo Medical and Dental University)H-Index: 5
Last. Akira Toyofuku (Tokyo Medical and Dental University)H-Index: 15
view all 15 authors...
Abstract Objective Atypical Odontalgia (AO) is a condition characterized by tooth pain with no apparent cause. Although psychiatric comorbidity seems to be very common, it has rarely been studied. To clarify the influence of psychiatric comorbidity on the clinical features in patients with AO, we retrospectively evaluated their examination records. Methods Clinical features and psychiatric diagnoses of 383 patients with AO were investigated by reviewing patients' medical records and referral let...
11 CitationsSource
#1Shinya Furukawa (Ehime University)H-Index: 25
#2T SakaiH-Index: 2
Last. Yoshihiro Miyake (Ehime University)H-Index: 45
view all 16 authors...
Depressive symptoms and prevalence of erectile dysfunction in Japanese patients with type 2 diabetes mellitus: the Dogo Study
10 CitationsSource
#1Giovanni CoronaH-Index: 83
#2Silvia BianchiniH-Index: 24
Last. Mario Maggi (UniFI: University of Florence)H-Index: 160
view all 5 authors...
There is evidence demonstrating that sexual complaints represent the most specific symptoms associated with late onset hypogonadism, while central obesity is the most specific sign. In obese men, hypogonadism can further worsen the metabolic profile and increase abdominal fat. In addition, although hypogonadism can exacerbate obesity-associated erectile dysfunction (ED), recent data suggest that a direct contribution of fat-derived factors could be hypothesized. In particular, an animal model re...
29 CitationsSource
#1Bruno Lunenfeld (BIU: Bar-Ilan University)H-Index: 43
#2George MskhalayaH-Index: 6
Last. Abraham Morgentaler (Harvard University)H-Index: 55
view all 7 authors...
Hypogonadism or Testosterone Deficiency (TD) in adult men as defined by low levels of serum testosterone accompanied by characteristic symptoms and/or signs as detailed further on can be found in long-recognized clinical entities such as Klinefelter syndrome, Kallmann syndrome, pituitary or testicular disorders, as well as in men with idiopathic, metabolic or iatrogenic conditions that result in testosterone deficiency. These recommendations do not encompass the full range of pathologies leading...
174 CitationsSource
Clinicians should be cognizant of the close relationship that exists between two of the most common endocrine disorders, primary hypothyroidism and diabetes mellitus. This applies to patients with both type 1 and type 2 diabetes mellitus (T1DM and T2DM respectively). However, the association is greater in T1DM, probably because of the shared autoimmune predisposition. In patients with T2DM, the relationship is somewhat weaker and the explanation less clear-cut. Factors such as dietary iodine def...
12 CitationsSource
#1Mario Maggi (UniFI: University of Florence)H-Index: 160
#2Jaques BuvatH-Index: 5
Last. Luiz Otavio TorresH-Index: 16
view all 5 authors...
ABSTRACT Introduction Besides hypogonadism, other endocrine disorders have been associated with male sexual dysfunction (MSD). Aim To review the role of the pituitary hormone prolactin (PRL), growth hormone (GH), thyroid hormones, and adrenal androgens in MSD. Methods A systematic search of published evidence was performed using Medline (1969 to September 2011). Oxford Centre for Evidence‐Based Medicine—Levels of Evidence (March 2009) was applied when possible. Main Outcome Measures The most imp...
87 CitationsSource
#1Yoshinobu Kanda (Jichi Medical University)H-Index: 38
Although there are many commercially available statistical software packages, only a few implement a competing risk analysis or a proportional hazards regression model with time-dependent covariates, which are necessary in studies on hematopoietic SCT. In addition, most packages are not clinician friendly, as they require that commands be written based on statistical languages. This report describes the statistical software ‘EZR' (Easy R), which is based on R and R commander. EZR enables the app...
5,446 CitationsSource
Cited By0
Newest