Photoacoustic stimulation with single neuron precision

Published on Mar 5, 2021
· DOI :10.1117/12.2578734
Linli Shi1
Estimated H-index: 1
(BU: Boston University),
Ying Jiang4
Estimated H-index: 4
(BU: Boston University)
+ 1 AuthorsChen Yang74
Estimated H-index: 74
(BU: Boston University)
Towards non-genetic, precise neural stimulation, we develop a photoacoustic neural stimulation technology. It employs a fiber-based optoacoustic process, in which pulsed light is delivered through an optical fiber into an absorbing layer coated at the tip, resulting in transient heating and generating a localized acoustic wave. We report photoacoustic stimulation in vitro and in vivo through a lab-built fiber based optoacoustic emitter (FOE). Single neuron optoacoustic neural modulation is achieved through a tapered FOE (TFOE) developed with negligible thermal deposition. TFOE single neuron stimulation is shown to be compatible with patch and provides insights towards mechanical modulation of neural systems.
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