A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML
Abstract
Leukemias bearing fusions of the AF10/MLLT10 gene are associated with poor prognosis, and therapies targeting these fusion proteins (FPs) are lacking. To understand mechanisms underlying AF10 fusion-mediated leukemogenesis, we generated inducible mouse models of acute myeloid leukemia (AML) driven by the most common AF10 FPs, PICALM/CALM-AF10 and KMT2A/MLL-AF10, and performed comprehensive characterization of the disease using transcriptomic,...
Paper Details
Title
A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML
Published Date
Jun 17, 2021
Journal
Volume
137
Issue
24
Pages
3403 - 3415
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