Simultaneous targeting of oxidative stress and fibrosis reverses cardiomyopathy‐induced ventricular remodelling and dysfunction

Background and Purpose Oxidative stress and fibrosis are hallmarks of cardiomyopathy‐induced heart failure yet are not effectively targeted by current frontline therapies. Here, the therapeutic effects of the anti‐oxidant, N ‐acetylcysteine (NAC), were compared and combined with an acute heart failure drug with established anti‐fibrotic effects, serelaxin (RLX), in a murine model of cardiomyopathy. Experimental Approach Adult male 129sv mice...