ADP-ribosylation of RNA and DNA: fromin vitrocharacterization toin vivofunction

Volume: 49, Issue: 7, Pages: 3634 - 3650
Published: Mar 8, 2021
Abstract
The functionality of DNA, RNA and proteins is altered dynamically in response to physiological and pathological cues, partly achieved by their modification. While the modification of proteins with ADP-ribose has been well studied, nucleic acids were only recently identified as substrates for ADP-ribosylation by mammalian enzymes. RNA and DNA can be ADP-ribosylated by specific ADP-ribosyltransferases such as PARP1–3, PARP10 and tRNA...
Paper Details
Title
ADP-ribosylation of RNA and DNA: fromin vitrocharacterization toin vivofunction
Published Date
Mar 8, 2021
Volume
49
Issue
7
Pages
3634 - 3650
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