Identifying loci with different allele frequencies among cases of eight psychiatric disorders using CC-GWAS
Abstract
Psychiatric disorders are highly genetically correlated, but little research has been conducted on the genetic differences between disorders. We developed a new method (case-case genome-wide association study; CC-GWAS) to test for differences in allele frequency between cases of two disorders using summary statistics from the respective case-control GWAS, transcending current methods that require individual-level data. Simulations and analytical...
Paper Details
Title
Identifying loci with different allele frequencies among cases of eight psychiatric disorders using CC-GWAS
Published Date
Mar 8, 2021
Journal
Volume
53
Issue
4
Pages
445 - 454
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