Analytical comparability assessment on glycosylation of ziv-aflibercept and the biosimilar candidate
Volume: 180, Pages: 494 - 509
Published: Jun 1, 2021
Abstract
Ziv-aflibercept (aflibercept) is a recombinant fusion protein which combines the portions of human vascular endothelial growth factor receptors extracellular domains fused to the Fc portion of human IgG1. It is a highly sialylated glycoprotein with 5 N-glycosylation sites. In this study, a comprehensive strategy for comparability study of the complex glycosylation was developed between aflibercept and the biosimilar candidate including the...
Paper Details
Title
Analytical comparability assessment on glycosylation of ziv-aflibercept and the biosimilar candidate
Published Date
Jun 1, 2021
Volume
180
Pages
494 - 509
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