A method for synthesis of polysubstituted 4-difluoromethyl and perfluoroalkyl pyrazoles
Abstract
A method for the synthesis of polysubstituted 4-difluoromethyl and perfluoroalkyl pyrazole derivatives by the Lewis acid- and base-co-mediated reaction of perfluoroacetyl diazoester with ketones is reported. A series of structurally diverse 4-difluoromethylated and perfluoroalkylated pyrazoles were obtained in moderate to good yields. The reactions proceeded smoothly under mild conditions with wide functional group...
Paper Details
Title
A method for synthesis of polysubstituted 4-difluoromethyl and perfluoroalkyl pyrazoles
Published Date
Apr 1, 2021
Journal
Volume
85
Pages
132062 - 132062
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