Investigation of urinary components in rat model of ketamine-induced bladder fibrosis based on metabolomics

Ketamine abuse has been linked to the system's damage, presenting with lower urinary tract symptoms (LUTS). While the pathogenesis of ketamine-induced urinary damage is not fully understood, fibrosis is believed to be a potential mechanism. A metabolomic investigation of the urinary metabolites in ketamine abuse was conducted to gain insights into its pathogenesis.A rat model of ketamine induced bladder fibrosis was established through tail vein...