Internal medicine

Receptor

Knockout mouse

Albuminuria

Podocyte

Diabetes mellitus

Endocrinology

Chemistry

Inflammation

Inflammasome

Proteinuria

Diabetic nephropathy

Kidney

Medicine

Metabolism

Nucleotide leukin-rich polypeptide 3 (NLRP3) inflammasome is documented as a potent target for treating metabolic diseases and inflammatory disorders. Our recent work demonstrated that inhibition of NLRP3 inflammasome activation inhibits renal inflammation and fibrosis in diabetic nephropathy. This study was to investigate the effect of NLRP3 inflammasome on podocyte injury and the underlying mechanism in diabetic nephropathy.

Inhibition of NLRP3 inflammasome ameliorates podocyte damage by suppressing lipid accumulation in diabetic nephropathy