Internal medicine

Pathogenesis

Rheumatic fever

Serology

Bacteria

Biology

Psychiatry

Antibody

Virology

Immunology

Streptococcus

Sequela

Group A

Acute rheumatic fever

Genetics

Medicine

Clinical Infectious Diseases

Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.

Serological Profiling of Group A <i>Streptococcus</i> Infections in Acute Rheumatic Fever

Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever