Targeting KRAS: The Elephant in the Room of Epithelial Cancers
Abstract
Mutations of the proto-oncogene KRAS are the most frequent gain-of-function alterations found in cancer. KRAS is mutated in about 30% of all human tumors, but it could reach more than 90% in certain cancer types such as pancreatic adenocarcinoma. Although historically considered to be undruggable, a particular KRAS mutation, the G12C variant, has recently emerged as an actionable alteration especially in non-small cell lung cancer (NSCLC). KRAS...
Paper Details
Title
Targeting KRAS: The Elephant in the Room of Epithelial Cancers
Published Date
Mar 11, 2021
Journal
Volume
11
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