Oxidative stress and inflammatory response of ghrelin on myocardial and aortic tissues in insulin-resistant rats

Objectives This study was designed to clarify the effects of ghrelin on myocardial and aortic tissues in insulin-resistant rats. Methods Sprague-Dawley rats were divided into the following groups: control (Group 1), insulin resistance (IR, Group 2), ghrelin (Group 3) and IR+Ghrelin (Group 4) groups. Levels of HOMA-IR, fibronectin, hydroxyproline, collagen-1, collagen-3, matrix metalloproteinase-3, and matrix metalloproteinase-9, and tissue...