Roles of nitric oxide and polyamines in brain tumor growth
Abstract
Nitric oxide (NO) and polyamines: putrescine, spermidine and spermine, are key arginine metabolites in mammalian tissues that play critical roles i.a. in regulation of vascular tone (NO), and cell cycle regulation (polyamines). In the brain, both classes of molecules additionally have neuromodulatory and neuroprotective potential, and NO also a neurotoxic potential. Here we review evidence that brain tumors use the NO- and polyamine-synthesizing...
Paper Details
Title
Roles of nitric oxide and polyamines in brain tumor growth
Published Date
Mar 1, 2021
Journal
Volume
66
Issue
1
Pages
199 - 205
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