Crumbs2 Is an Essential Slit Diaphragm Protein of the Renal Filtration Barrier

Volume: 32, Issue: 5, Pages: 1053 - 1070
Published: May 1, 2021
Abstract

Background

Crumbs2 is expressed at embryonic stages as well as in the retina, brain, and glomerular podocytes. Recent studies identified CRB2 mutations as a novel cause of steroid-resistant nephrotic syndrome (SRNS).

Methods

To study the function of Crb2 at the renal filtration barrier, mice lacking Crb2 exclusively in podocytes were generated. Gene expression and histologic studies as well as transmission and scanning...
Paper Details
Title
Crumbs2 Is an Essential Slit Diaphragm Protein of the Renal Filtration Barrier
Published Date
May 1, 2021
Volume
32
Issue
5
Pages
1053 - 1070
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