Development of a High‐Affinity Antibody‐Binding Peptide for Site‐Specific Modification

Volume: 16, Issue: 11, Pages: 1814 - 1821
Published: Mar 25, 2021
Abstract
Immunoglobulin G (IgG)-binding peptides such as 15-IgBP are convenient tools for the site-specific modification of antibodies and the preparation of homogeneous antibody-drug conjugates. A peptide such as 15-IgBP can be selectively crosslinked to the fragment crystallizable region of human IgG in an affinity-dependent manner via the ϵ-amino group of Lys8. Previously, we found that the peptide 15-Lys8Leu has a high affinity (Kd =8.19 nM) due to...
Paper Details
Title
Development of a High‐Affinity Antibody‐Binding Peptide for Site‐Specific Modification
Published Date
Mar 25, 2021
Volume
16
Issue
11
Pages
1814 - 1821
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