Betahydroxybutyrate Consumption in Autopsy Brain Tissue from Alzheimer’s Disease Subjects

Alzheimer's disease (AD) features perturbed brain glucose utilization, which could contribute to brain bioenergetic failure. This led some to consider using ketone bodies to enhance AD brain bioenergetics and treat AD.We evaluated the rate at which brain homogenates from persons with Alzheimer's disease (AD) metabolize D-β-hydroxybutyrate (BHB).We homogenized pieces of temporal cortex from frozen autopsy brains obtained from recently deceased AD...