The role of lysosomal ion channels in lysosome dysfunction

Lysosomes offer a unique arrangement of degradative, exocytic, and signaling capabilities that make their continued function critical to cellular homeostasis. Lysosomes owe their function to the activity of lysosomal ion channels and transporters, which maintain concentration gradients of H+, K+, Ca2+, Na+, and Cl− across the lysosomal membrane. This review examines the contributions of lysosomal ion channels to lysosome function, showing how...