Interleukin-6 controls recycling and degradation, but not internalization of its receptors
Abstract
Interleukin-6 (IL-6) is a cytokine implicated in proinflammatory as well as regenerative processes and acts via receptor complexes consisting of the ubiquitously expressed, signal-transducing receptor gp130 and the IL-6 receptor (IL-6R). The IL-6R is expressed only on hepatocytes and subsets of leukocytes, where it mediates specificity of the receptor complex to IL-6 as the subunit gp130 is shared with all other members of the IL-6 cytokine...
Paper Details
Title
Interleukin-6 controls recycling and degradation, but not internalization of its receptors
Published Date
Jan 1, 2021
Volume
296
Pages
100434 - 100434
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