Ciliary neurotrophic factor overexpression protects the heart against pathological remodelling in angiotensin II-infused mice

Volume: 547, Pages: 15 - 22
Published: Apr 1, 2021
Abstract
Ciliary neurotrophic factor (CNTF), which is a neural peptide, has been reported to confer cardioprotective effects. However, whether CNTF-based gene therapy could prevent cardiac remodelling remains incompletely clear. In this study, we used adeno-associated viral vector serotype 9 (AAV9)-based cardiac gene therapy to test the effects of CNTF overexpression on adverse ventricular remodelling in angiotensin II (Ang II)-infused mice. First,...
Paper Details
Title
Ciliary neurotrophic factor overexpression protects the heart against pathological remodelling in angiotensin II-infused mice
Published Date
Apr 1, 2021
Volume
547
Pages
15 - 22
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