Catalytic asymmetric reductive hydroalkylation of enamides and enecarbamates to chiral aliphatic amines.
Abstract
To increase the reliability and success rate of drug discovery, efforts have been made to increase the C(sp3) fraction and avoid flat molecules. sp3-Rich enantiopure amines are most frequently encountered as chiral auxiliaries, synthetic intermediates for pharmaceutical agents and bioactive natural products. Streamlined construction of chiral aliphatic amines has long been regarded as a paramount challenge. Mainstream approaches, including...
Paper Details
Title
Catalytic asymmetric reductive hydroalkylation of enamides and enecarbamates to chiral aliphatic amines.
Published Date
Feb 26, 2021
Journal
Volume
12
Issue
1
Pages
1313
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