Catalytic asymmetric reductive hydroalkylation of enamides and enecarbamates to chiral aliphatic amines.

Volume: 12, Issue: 1, Pages: 1313
Published: Feb 26, 2021
Abstract
To increase the reliability and success rate of drug discovery, efforts have been made to increase the C(sp3) fraction and avoid flat molecules. sp3-Rich enantiopure amines are most frequently encountered as chiral auxiliaries, synthetic intermediates for pharmaceutical agents and bioactive natural products. Streamlined construction of chiral aliphatic amines has long been regarded as a paramount challenge. Mainstream approaches, including...
Paper Details
Title
Catalytic asymmetric reductive hydroalkylation of enamides and enecarbamates to chiral aliphatic amines.
Published Date
Feb 26, 2021
Volume
12
Issue
1
Pages
1313
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