A multicompartment model for intratumor tissue‐specific analysis of DCE‐MRI using non‐negative matrix factorization

Purpose A pharmacokinetic analysis of dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) data is subject to inaccuracy and instability partly owing to the partial volume effect (PVE). We proposed a new multicompartment model for a tissue‐specific pharmacokinetic analysis in DCE‐MRI data to solve the PVE problem and to provide better kinetic parameter maps. Methods We introduced an independent parameter named fractional volumes of...