Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells
Abstract
Macrophage autophagy is a highly anti-atherogenic process that promotes the catabolism of cytosolic lipid droplets (LDs) to maintain cellular lipid homeostasis. Selective autophagy relies on tags such as ubiquitin and a set of selectivity factors including selective autophagy receptors (SARs) to label specific cargo for degradation. Originally described in yeast cells, "lipophagy" refers to the degradation of LDs by autophagy. Yet, how LDs are...
Paper Details
Title
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells
Published Date
Feb 26, 2021
Journal
Volume
17
Issue
11
Pages
3671 - 3689
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