Bone material properties and response to teriparatide in osteoporosis due to WNT1 and PLS3 mutations

Patients with osteoporosis-associated WNT1 or PLS3 mutations have unique bone histomorphometric features and osteocyte-specific hormone expression patterns. To investigate the effects of WNT1 and PLS3 mutations on bone material properties. Transiliac bone biopsies were evaluated by quantitative backscattered electron imaging, immunohistochemistry, and bone histomorphometry. Ambulatory patients. Three pediatric and eight adult patients with WNT1...