Antiphospholipid Syndrome of Bilateral Nonarteritic Anterior Ischemic Optic Neuropathy Patient Deteriorating Over Time.

Published on Feb 18, 2021in Korean Journal of Ophthalmology
· DOI :10.3341/KJO.2020.0100
Yong-Wun Cho2
Estimated H-index: 2
(Gyeongsang National University),
Byoung Seon Kim2
Estimated H-index: 2
(Gyeongsang National University)
+ 2 AuthorsIn Young Chung8
Estimated H-index: 8
(Gyeongsang National University)
#1Anne S. Abel (UMN: University of Minnesota)H-Index: 4
#2Collin M. McClelland (UMN: University of Minnesota)H-Index: 13
Last. Michael J. Lee (UMN: University of Minnesota)H-Index: 86
view all 3 authors...
Abstract Typical optic neuritis is an idiopathic demyelinating condition that is often associated with multiple sclerosis. This has been well characterized and has an excellent prognosis. Atypical optic neuritis can result from an inflammatory, infectious, or autoimmune disorder. Differentiating the two types of optic neuritis is paramount and may be challenging early on in the clinical course. This review describes the recent literature describing the pathophysiology, clinical presentation, neu...
17 CitationsSource
#1Crandall E. Peeler (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 6
#2Dean M. Cestari (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 18
Non-arteritic anterior ischemic optic neuropathy (NAION) is a relatively common optic neuropathy in adults over the age of 50, typically causing sudden, painless, unilateral vision loss and always resulting in swelling of the optic nerve head. Though several anatomic and vascular risk factors have been identified, much remains unknown about its pathophysiology and there is no proven treatment. This article reviews the risk factors, clinical presentation, and therapies that have been investigated...
8 CitationsSource
#1M. Serrador-García (Hospital Clínico San Carlos)H-Index: 7
#2Enrique Santos-Bueso (Hospital Clínico San Carlos)H-Index: 13
Last. J. García-Sánchez (Hospital Clínico San Carlos)H-Index: 18
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Abstract Case report We report the case of a young patient with unilateral anterior ischemic optic neuropathy, with no known cardiovascular risk factors and visual acuity, preserved with positive anticardiolipin antibodies as a unique find. Discussion Non-arteritic anterior ischemic optic neuropathy in the context of antiphospholipid syndrome is an uncommon finding, but it must be considered in the diagnosis of the atypical anterior ischemic optic neuropathy.
3 CitationsSource
#1Betul TugcuH-Index: 9
#2Nur AcarH-Index: 14
Last. Fadime Ulviye YigitH-Index: 6
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Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by vascular thrombosis or pregnancy morbidity. Ocular involvement in APS includes a broad spectrum of manifestations involving anterior and posterior segment or the presence of neuroophthalmologic features. Nonarteritic anterior ischemic optic neuropathy (NAION) is a very rare finding, and in this report a case having NAION as the prevailing sign of APS is presented. A middle-aged women who presented with visual disturbances...
11 CitationsSource
#1Virginia Miraldi Utz (Case Western Reserve University)H-Index: 9
#2Johnny Tang (Visual Sciences)H-Index: 15
Antiphospholipid syndrome (APS) is an autoimmune disease characterised by a heterogenous group of antibodies directed against negatively charged phospholipids including antiphospholipid antibodies (aPL), anticardiolipin antibodies (aCL) and β-2 glycoprotein I (aβ-2-GP1). The major features of this disorder include arterial and venous thrombosis and recurrent fetal loss. The vasculature of the eye is frequently involved and may be the presenting manifestation. A diagnosis of APS should be conside...
34 CitationsSource
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