Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance
Abstract
Mitochondrial DNA double-strand breaks (mtDSBs) are toxic lesions that compromise the integrity of mitochondrial DNA (mtDNA) and alter mitochondrial function1. Communication between mitochondria and the nucleus is essential to maintain cellular homeostasis; however, the nuclear response to mtDSBs remains unknown2. Here, using mitochondrial-targeted transcription activator-like effector nucleases (TALENs)1,3,4, we show that mtDSBs activate a...
Paper Details
Title
Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance
Published Date
Feb 24, 2021
Journal
Volume
591
Issue
7850
Pages
477 - 481
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