Cholangiocyte organoids can repair bile ducts after transplantation in the human liver.
Abstract
Organoid technology holds great promise for regenerative medicine but has not yet been applied to humans. We address this challenge using cholangiocyte organoids in the context of cholangiopathies, which represent a key reason for liver transplantation. Using single-cell RNA sequencing, we show that primary human cholangiocytes display transcriptional diversity that is lost in organoid culture. However, cholangiocyte organoids remain plastic and...
Paper Details
Title
Cholangiocyte organoids can repair bile ducts after transplantation in the human liver.
Published Date
Feb 19, 2021
Journal
Volume
371
Issue
6531
Pages
839 - 846
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Notes
History