Internal medicine

Receptor

Menstrual cycle

Population

Uterine bleeding

Obstetrics

Ulipristal acetate

Hormone antagonist

Antagonist

Family planning

Gynecology

Menstrual bleeding

Uterine fibroids

Research methodology

Hormone

Medicine

Environmental health

New England Journal of Medicine

Uterine fibroids are a common cause of heavy menstrual bleeding and pain. Treatment with the combination of relugolix (an oral gonadotropin-releasing hormone-receptor antagonist), estradiol, and norethindrone acetate, administered once daily, may have efficacy in women with uterine fibroids and heavy bleeding while avoiding hypoestrogenic effects.

Treatment of Uterine Fibroid Symptoms with Relugolix Combination Therapy