Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF
Abstract
TRIM24 is a transcriptional regulator as well as an E3 ubiquitin ligase. It is overexpressed in diverse tumors, and high expression levels have been linked to poor prognosis in breast cancer patients. TRIM24 contains a PHD/bromodomain offering the opportunity to develop protein interaction inhibitors that target this protein interaction module. Here we identified potent acetyl-lysine mimetic benzimidazolones TRIM24 bromodomain inhibitors. The...
Paper Details
Title
Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF
Published Date
May 20, 2015
Volume
59
Issue
4
Pages
1642 - 1647
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